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More than 150,000 Americans suffer from hereditary or sporadic ataxia in the United States and being able to better understand the genetic diversity allows us to gain insight on a system level into genes and cellular pathways that result in neurodegeneration, said Puneet Opal , MD, PhD, neurologist at Northwestern Memorial Hospital. Ataxia often occurs when parts of the nervous system that control movement are damaged. an update on reasonable how to prepare for job interview productsPeople with ataxia experience a failure of muscle control in their arms and legs, resulting in a lack of balance and coordination or a disturbance of gait, according to the National Institute of Neurological Disorders and Stroke . To better diagnose and treat patients with ataxia, co-authors Opal and former Northwestern Medicine researcher and current University of California San Francisco School of Medicine adjunct professor Alessandro Didonna, PhD, reviewed the genetic makeup of ataxias syndrome and the use of genetic sequencing and computer driven bioinformatics over the last 150 years. With the major advances in gene sequencing, a clearer understanding of ataxias through The Human Genome Project, the first successful undertaking to precisely sequence the human genetic code by solving the 3 billion letters in human DNA, and next generation sequencing (NGS), first commercially available sequencing technology that helps to identify genes with underlying genetic syndromes, helps provided additional insight on ataxia. The Human Genome Project was launched in 1998 to be able to read natures complete genetic blueprint for building a human being. The ability to catalog the first full human DNA sequence inspired another approach for genome analysis called NGS which became available to researchers in 2007. This technology allowed scientists to make large scale whole genome sequencing through a computerized system that is faster, more in-depth and cost-effective. The co-authors also discovered that cellular pathways and protein networks in ataxias exist in the genes. This discovery helped to better understand how aging plays a role in the risk for neurogenerative diseases like ataxia.
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